postoperative cognitive dysfunction
Conditions
Interventions
Case series:Case series
Sponsors
Xuzhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. non-cardiac surgery patients; 2. Aged between 60 and 85 years old; 3. Han Nationality, mother tongue is Chinese; 4. American Society of Anesthesiologists (ASA) grade I or II; 5. To be expected with at least 5 days of hospital stay; 6. MMSE score: illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points; 7. Geriatric Depression Scale (GDS) grade 1 or 2; 8. signed informed consent.
Exclusion criteria
Exclusion criteria: 1. history of a clear neurological disease, mental illness or abnormal personality that precluded the ability to complete the baseline cognitive assessment, such as senile dementia, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc; 2. have a severe head and face disease, a history of trauma or surgery; 3. history of severe physical illness and drug dependence, alcoholism; 4. significant impairments of vision,hearing or motor skills (such as hemiplegia).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a battery of neuropsychological tests;homocysteine and metabolic enzymes;homocysteine and metabolic enzymes;chemokines;metal matrix proteases and inhibitors;brain-derived neurotrophic factors; | — |
Countries
China
Contacts
Public ContactCao Junli
Xuzhou Medical Univetsity
Outcome results
None listed