Sepsis, acute respiratory distress syndrome
Conditions
Interventions
Low dose group:Ulinastatin 400000 units/day
High dose group:Ulinastatin 800000 units/day
Sponsors
The Third Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) aged 18 to 70 years old, men and women; (2) in accordance with the above sepsis ARDS diagnostic criteria; (3) sepsis diagnosed ARDS to include test time 12 hours or less; (4) all needs to accept patients with endotracheal intubation and ventilator help to breathe.
Exclusion criteria
Exclusion criteria: (1) pregnant women, lactation and possible pregnancy women; (2) influence the survival of the patients with severe illness (for example, unresectable tumors, blood disease, cerebrovascular disease, leading to long-term lie in bed, dementia, etc.); (3) acute myocardial infarction (< 1 week); (4) with acute renal failure; (5) AECOPD; (6) from pulmonary fibrosis; (7) clear of valvular heart disease and heart failure; (8) drug allergies; (9) in patients with mental illness; (10) doctors recorgnized not eligible for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bedside ultrasound lung lung water index;PICCO blood vessels outside the lung water (EVLWI) and pulmonary permeability index (PVPI);Bronchoalveolar lavage fluid protein content determination;Vascular permeability related factor (ET - 1, TM, vWF);Blood gas analysis (PO2 / FiO2, PO2 (A - A)); | — |
Secondary
| Measure | Time frame |
|---|---|
| 28 days survival rate;The length of time;Mechanical ventilation time;APACHE II score;SOFA score; | — |
Countries
China
Contacts
Public ContactWang Zhiyong
The Third Hospital of Hebei Medical University
Outcome results
None listed