Primary hyperlipidemia
Conditions
Interventions
treatment group:Jiangzhi Tongluo soft capsules
control group:Pushen capsules
Sponsors
Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Meet the criteria of Western diagnosis of primary hyperlipidemia; (2) In line with TCM qi stagnation and blood stasis syndrome; (3) The fasting LDL-C=4.14mmol/L, TC=6.22mmol/L, TG=2.26mmol/L, and the difference between two times should not exceed 12% ; (4) Lipid-lowering drugs or other lipid-lowering measures to disable at least 4 weeks; (5) Dietary evaluation of patients with hyperlipidemia = 5 points; (6) Aged 18 ~ 70 years male and female; (7) Those who volunteered and signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Secondary dyslipidemia due to systemic diseases such as diabetic hypothyroidism, Cushing's syndrome, liver and kidney disease, systemic lupus erythematosus, myeloma, excessive alcohol consumption caused dyslipidemia; (2) Drug-induced secondary dyslipidemia: such as thiazide diuretics, ß-blockers, long-term heavy use of glucocorticoid and some contraceptives; (3) Heparin, thyroxine, and other drugs that affect blood lipid metabolism are being used, and anticoagulants are required for long-term clinical trials. (4) Familial hypercholesterolemia patients; (5) Those with acute coronary syndromes (such as myocardial infarction, unstable angina, etc.) or acute cerebrovascular accidents (such as stroke history) in the past 6 months and those with other serious cardiovascular diseases, or in the past 18 months had PCI and CABG and other major surgery; (6) Patients with unstable diabetic glycemic control, HbA1c> 7%, or diabetic complications (diabetic nephropathy, peripheral neuropathy) requiring medication control; (7) patients with severe liver and kidney dysfunction (ALT, AST> 1.5 times the upper limit of normal, Cr> upper limit of normal); (8) Hypertensive patients with poor drug control (blood pressure level after treatment: systolic blood pressure =160mmHg, diastolic blood pressure> 90mmHg) or hypotension (resting sitting blood pressure) <90 / 50mmHg; (9) Persons with mental illness, alcohol dependence or history of drug abuse; (10) Pregnant and lactating women and during their medication or within 3 months after the cessation of medication to prepare their children; (11) Allergy or previous allergy to many drugs, or allergic to the components of the study medication; (12) 3 months prior to the trial participated in other clinical studies; (13) Patients who other researchers think should not be involved in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Low-density lipoprotein; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total Cholesterol;Triglyceride;High-density lipoprotein;TCM Syndrome Score;Chinese medicine symptoms;The incidence of cardiovascular events; | — |
Countries
China
Contacts
Public ContactGuoqing Ma
Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
Outcome results
None listed