Stroke,symptomatic intracranial atherosclerotic stenosis
Conditions
Interventions
1:Remote ischemic conditioning is composed of a given cycle of 5-min bilateral upper limb ischemia intervened by 5-min reperfusion, which is induced by an automated cuff-inflator (Doctormate) placed o
2:Remote ischemic conditioning is composed of a given cycle of 3-min bilateral upper limb ischemia intervened by 3-min reperfusion, which is induced by an automated cuff-inflator (Doctormate) placed o
3:Routine treatment, do not carry out remote ischemia conditioning training
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with an ischemic stroke or TIA before admission and the following requirements should be satisfied as well: (1) The occurrence of an ischemic stroke within 30 days; (2) NIHSS score=7; (3) Patients with symptomatic intracranial atherosclerotic stenosis (sIAS).
Exclusion criteria
Exclusion criteria: 1. Intracranial abnormalities such as tumor, abscess, vascular malformation, cerebral venous sinus stenosis or thrombosis; 2. Previous history of major surgery within 30 days prior to inclusion; 3. Pregnant or lactating women; 4. Life expectancy < 30 days due to concomitant life-threatening illness; 5. Severe hemostatic or coagulation disorders; 6. Contraindications for remote ischemic conditioning: significant peripheral arterial disease, soft tissue or vascular injury, wounds, and fracture affecting the upper limbs; 7. Patients unlikely to be compliant with intervention or return for follow-up visits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrent rate of ischemic stroke and/or transient ischemic attack [ Time Frame: baseline, within 12 months ]; | — |
Secondary
| Measure | Time frame |
|---|---|
| The neurological impairment caused by a stroke will be assessed by National Institutes of Health Stroke Scale (NIHSS);The degree of disability will be assessed by modified Rankin Scale (mRS);he performance in activities of daily living will be assessed by Barthel Index (BI) scale.;Transcranial Cerebral Doppler (TCD); | — |
Countries
China
Contacts
Public ContactHong Chang
Xuanwu Hospital, Capital Medical University
Outcome results
None listed