glioblastoma
Conditions
Interventions
single arm:Taking apatinib
Sponsors
Xijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. age greater than 18 years, less than 75 years; 2. pathological diagnosis of glioblastoma; 3. patients who were not willing to receive chemotherapy after surgery or the patients who had relapsed in the course of treatment of STUPP regimen or after treatment; 4. ECOG score: 0-2 points; 5. more than the expected survival time in March; 6. the main organ function is normal, which is in accordance with the following criteria: (1)the standard of blood routine examination should be conformed (no blood transfusion and blood products within 14 days, no correction of G-CSF and other hematopoietic stimulators): HB = 90 g/L; ANC = 1.5 * 10^9/L; PLT = 80*10^9/L; (2)biochemical examination should comply with the following criteria: TBIL 45 ml/min (Cockcroft-Gault formula); 7. subjects volunteered to join the study and signed informed consent. The compliance was good and followed up.
Exclusion criteria
Exclusion criteria: 1. pregnant or lactating women 2. with high blood pressure and the antihypertensive drug treatment can not be reduced to the normal range (systolic pressure >140 diastolic mmHg >90 mmHg) with I at or above the level of myocardial ischemia or myocardial infarction arrhythmia (including QT interval = 440 MS) and II heart function insufficiency 3. factors that have an obvious influence on the absorption of oral drugs such as inability to swallow chronic diarrhea and intestinal obstruction, etc. 4. abnormal coagulation function (INR > 1.5 or prothrombin time (PT) > ULN+4 sec or APTT >1.5 ULN) with bleeding tendency or undergoing thrombolytic or anticoagulant therapy 5. uncontrolled epilepsy 6. severe uncontrolled recurrent infection or other serious uncontrolled accompanying diseases 7. researchers judge other possible effects on clinical studies and findings
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 6 months of disease free survival rate;Objective remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total survival for 2 yearsTotal survival for 2 years;Disease control rate; | — |
Countries
China
Contacts
Public ContactMei Shi
Xijing Hospital
Outcome results
None listed