refractory chronic sinusitis
Conditions
Interventions
Case series:clarithromycin
Sponsors
Beijing Tongren Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 to 65 years; 2. The patient with chronic sinusitis underwent endoscopic sinusitis surgery suffer from nasal obstruction, nasal discharge and headache after using antibiotics preventively (3 days), nasal irrigation, intranasal corticosteroid and mucolytic agent, and the symptoms are persistent for one month even using oral corticosteroid; 3. The total number or percentage of eosinophilic granulocyte in blood routine test are normal
Exclusion criteria
Exclusion criteria: 1. the patients had a history of cystic fibrosis, primary ciliary dyskinesia, immune deficiency; 2. combining with severe allergic rhinitisfugal sinusitis; 3. pregnant and breastfeeding women; 4. taking medication with adverse interaction with macrolides or with a history of macrolide hypersensitivity; 5. combining with liver, kidney or digestive tract disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS;SNOT-22;Lund-kennedy; | — |
Countries
China
Contacts
Public ContactBing Zhou
Beijing Tongren Hospital, Capital Medical University
Outcome results
None listed