Postoperative Delirium and Postoperative Cognitive Dysfunction
Conditions
Sponsors
The Third Hospital of Xiangya
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. patients will have elective hip or knee replacement surgery or colorectal?cancer resection surgery; 2. aged 60-90 years, regardless and race; 3. Estimated hospital stay >= 7 days; 4. no immune system disease; 5. Agree to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. patient or family member's refusal and attitude unknown; 2. Dukes D of colorectal cancer; 3. are participating in other clinical trials; 4. the frequency of surgery is more than 1 times or need emergency surgery; 5. Dementia or Parkinson's disease or other neurological disorders that cause dysfunction; 6. preoperative coma, severe dementia, speech impairment, severe hearing or visual impairment, end-stage disease can not communicate; 7. antibiotics, probiotics, gastrointestinal motility drugs have been used within 10 days before admission; 8. suffering from acute pancreatitis or will have pancreatic surgery; 9. symptoms of intestinal obstruction or confirmed intestinal obstruction; 10. requires a long time of total parenteral nutrition after surgery; 11. Serious condition (preoperative ASA classification >= IV level); severe renal impairment (requiring renal replacement therapy); severe hepatic impairment (Child-Pugh grading C); 12. The attending physician or researcher believes there are other conditions that should not be included in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium;Postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| The composition and change of fecal flora;Systemic inflammation level;Postoperative gastrointestinal function recovery time;Quality of life; | — |
Countries
China
Contacts
Public ContactOu Yangwen
Xiangya Medical College, Cental South University
Outcome results
None listed