the sensitivity to anesthetics
Conditions
Interventions
high sevoflurane sensitivity group:NA
high sevoflurane resistivity group:NA
normal sevoflurane sensitivity group:NA
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18-65 years; 2. Undergoing elective general surgery with general anesthesia; 3. American Society of Anesthesiologists physical status I to III; 4. The duration of surgery being over 2 hours; 5. With informed consent.
Exclusion criteria
Exclusion criteria: 1. Any neurological disease; 2. Any psychological diseasewith antipsychotics; 3. Alcohol or drug addictions; 4. Usage of sedatives; 5. Allergic to inhaled anesthetics; 6. Family history of Malignant Hyperthermia; 7. Serious cardiovascular diseases; 8. Renal or hepatic dysfunction; 9. Participated in other clinical trial in 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| dosage of sevoflurane;exons sequence;Mitochondrial DNA sequence;metabolomics study; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time ratio of light sedation;Time ratio of deep sedation;Time ratio of proper sedation;Time to eye-opening;Time to extubation;Time to leaving OR;average concentration of EtSevo;sensitivity to sulfentanyl;sensitivity to atracurium;morbidity of complications; | — |
Countries
China
Contacts
Public ContactYUNXIA ZUO
Department of Anesthesiology, West China Hospital, Sichuan University
Outcome results
None listed