heart failure
Conditions
Interventions
2: LCZ696
Sponsors
Tianjin First Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) in the diagnosis and treatment of heart failure in China guide 2014, "the diagnosis standard of CHF, and the two dimensional doppler ultrasound and ultrasound echocardiography figure, electrocardiogram, laboratory examination, biological markers such as b-type natriuretic peptide (BNP) and other auxiliary examination confirmed, the course of seven years or less; (2) the combination of light, moderate renal impairment (30 mL (1.73 m2) min/mL or less glomerular filtration rate (GFR) < 90 mL/min (1.73 m2)] [9]; (3) New York heart association (NYHA), cardiac function class for II~ III[8]. Aged 40 ~ 75 years old; Body mass index (BMI) < 30kg/m2; In the left ventricular ejection fraction (LVEF) is less than or equal to 50%; Not within 3 months prior to entry.
Exclusion criteria
Exclusion criteria: 1. renal or hepatic primary disease, hyperkalemia (blood potassium > 5.5 mmol/L), rheumatic disease, malignant tumor, Acute infection, hypotension (less than 90/60 mmHg), autoimmune disease, anemia, etc. 2. Allergic or allergic to the study; 3. complicating acute coronary syndromes (ACS), hypertrophic obstructive cardiomyopathy (HOCM), severe arrhythmia and heart diseases such as rheumatic heart valve disease (RHVD); At admission, SCr > 265 mu mol/L; The person who has a poor compliance with sex is unable to use the prescribed medicine;6. Plasma BNP < 35 ng/L.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bnp;creatinine;EF;eGFR; | — |
Countries
China
Contacts
Public ContactLu Chengzhi
Tianjin First Central Hospital
Outcome results
None listed