Sepsis
Conditions
Interventions
High-dose group :Vitamin C 150mg / (kg * d)
Low-dose group:Vitamin C 50mg / (kg * d)
Placebo group :ormal saline
Sponsors
1st affiliated Hospital of Dalian Medical university
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Sepsis-3 criteria from Society of Critical Care Medicine (SCCM) /European Society of Intensive Care Medicine (ESICM); 2. Aged over 18 years; 3. ICU stay =96h; 4. obtain informed consent.
Exclusion criteria
Exclusion criteria: 1. There are contraindications for intravenous infusion of high-dose of vitamin c, such as severe nausea and vomiting, severe arrhythmia (VT, VF) as well as G6PD deficiency, PNH; 2. The estimated survival time <96h; 3. CRRT within the stay of the first 96h; 4. Previous immunodepressant within 6 months before study entry or Receipt of a solid-organ or bone marrow transplant; 5. Previous glucocorticosteroid within 7 days before study entry, more than Methylprednisolone (or convert to Methylprednisolone) =20mg/day; 6. Participation in an investigational clinical trial within 30 days; 7. Cannot finish the study (Expected survival < 96 hours or refuse treatment).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 Days Mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Survival rate in ICU;SOFA score;APACHE II;MODS score;Duration of mechanical ventilation;ICU stay;Hospital stay; | — |
Countries
China
Contacts
Public ContactXianyao Wan
1st affiliated Hospital of Dalian Medical university
Outcome results
None listed