erosive oral lichen planus
Conditions
Interventions
initial periodontal treatment combined with immunosuppressant group:initial periodontal treatment combined with immunosuppressant for the treatment of oral lichen planus
immunosuppressant group:immunosuppressant for the treatment of oral lichen planus
Sponsors
Department of Periodontology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National C
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Subjects aged 18-65 years old; 2. Oral lesions confined to the gums or gingival groove and other parts, generally symmetrical, white or gray-white papules, plaques, mesh, ring type, which can be accompanied by hyperemia, erosions, vesicular lesions; at the same time or separately in the skin, finger (toe) a part of the damage, skin damage to purple-red polygonal flat papules, finger (toe) in a thumb, deck atrophy thinning and dull, there are serious fissure formation; 3. Pathologically excessive orthokeratinized epithelial hyperkeratosis or not, spinous layer hyperplasia or atrophy, liquefaction degeneration of the basal cell layer, lamina propria lymphocyte infiltration strip; 4. Clinical damage of oral lichen planus score the first diagnosis fraction more than 5 points.
Exclusion criteria
Exclusion criteria: 1. any history of systemic disease (e.g., diabetes, hypertension, cardiovascular disease); 2. use any of Antibiotics, hormones or immunomodulators 3 months before; 3. subjects who with any other mucosal diseases in the mouth; 4. a history of allergies to immunosuppressants or regulators; 5. subjects who had received periodontal treatment within the last 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical damage score of oral lichen plants on gingiva; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale;Probing depth;Loss of attachment;Bleeding on probing index; | — |
Countries
China
Contacts
Public ContactSong Zhongchen
Department of Periodontology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National C
Outcome results
None listed