Branch vein occlusion macular edema
Conditions
Interventions
1:razorumab combined with macular laser photocoagulation
2:razorumab alone
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 76 Years
Inclusion criteria
Inclusion criteria: Patient selection criteria: 1) Informed consent must be signed before performing any study-related assessments; 2) Adult males or females aged 18 years or older; Eye selection criteria: Research Institute 3) Within 12 months prior to the screening visit, the study eye was diagnosed with visual impairment due to macular edema secondary to BRVO; 4) BCVA 24 to 73 ETDRS letters for screening and baseline visits; 5) The central retinal thickness measured by OCT was> 250 um; Contralateral eye 6) In the screening, the contralateral fundus BCVA = 34 ETDRS letters.
Exclusion criteria
Exclusion criteria: Patients who meet one of the following criteria are not eligible for inclusion in this study: 1) Research or follow-up procedures can not be followed; 2) Pregnant or lactating women, as well as women who do not take effective contraceptive methods are fertile women; 3) Screening The patients had a history of stroke or myocardial infarction within 3 months before the visit; 4) Renal failure or creatinine levels> 2.0 mg / dl; 5) Uncontrolled high blood pressure; 6) Active eye infections or intraocular inflammation of any eye; 7) iris neovascularization or neovascular glaucoma in any one eye; 8) any eye of uveitis or vitreous macular traction, macular epiretinal history; 9) In the first 3 months before the baseline visit, either eye received anti-angiogenic drug therapy; 10) studied eye glaucoma or IOP >24 mmHg; 11) study of diabetic retinopathy; 12) Other test drugs were used within 30 days before baseline visit; systemic anti-VEGF drugs were used within 6 months prior to baseline visit; 13) Study eyes received laser photocoagulation or intraocular surgery within 3 months prior to baseline; 14) with a history of lens research and aphakic or pseudo-crystalline eyes (within 3 months prior to screening) with vitreous corticosteroid treatment history; 15) Study the history of vitrectomy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Edema height; | — |
Countries
China
Contacts
Public ContactYu Xiaobing
Beijing Hospital
Outcome results
None listed