Treatment-resistant depression
Conditions
Interventions
Two groups:Auricular electro-acupuncture plus Sertraline versus Sertraline alone
Sponsors
Guang An Men Hospital of China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic standard "Depressive episode, the Handbook of Mental Disorders Statistics and Diagnosis, DSM-5"; 2. The total score of Hamilton Depressive Scale (HAMD-24) =17 points; 3. With reference to Thase and Rush criteria, the TRD must meet one of the following criteria: (1) Based on the medical history,at least Two kinds of adequate, full course (>3 months) of different structures of antidepressant treatment ineffective; (2) in a sufficient amount of antidepressants,enough treatment (>3 months) treatment is invalid, for another HAMD-24 scores 6 weeks); (3) For patients with first episode, two different structures of antidepressants in sufficient quantity and duration of treatment (> 6 weeks) ineffective. 4. Meet the TRD diagnostic criteria, aged 18-55 years of patients with Treatment-resistant depression, male or female; 5. Clinical examination and related laboratory tests showed no abnormalities; 6. Right hand; 7. Not previously taken the medicines of which used in this study; 8. Agree and sign informed consent form.
Exclusion criteria
Exclusion criteria: 1. Bipolar affective disorder, schizoaffective disorder,schizophrenia or other psychotic disorders; 2. A history of seizures or strong positive family history of epilepsy; 3. Serious physical illness or organic brain disease; 4. Serious Impotence,suicide or self-injury risk; 5. History of abuse of alcohol dependence or other active substances, while taking other psychotropic drugs (such as antipsychotics,mood stabilizers or central stimulants, etc.); 6. pregnant, preparing for pregnancy or Lactation; 7. past the body of metal implants; 8. into the group before January received a modified electrical shock or transcranial magnetic, DC stimulation therapy and other physical therapy; 9. included in the study before January have participated Other drug research in clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depressive Scale, HAMD-24; | — |
Countries
China
Contacts
Public ContactJiliang Fang
Guang An Men Hospital of China Academy of Chinese Medical Sciences
Outcome results
None listed