Influences of Organic Cation Transporter Polymorphisms on the Population Pharmacokinetics of Metformin in Patients with Type 2 Diabetes Mellitus

Status

Recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1800014273

Enrollment

Unknown

Registered

2018-01-02

Start date

2018-01-02

Completion date

Unknown

Last updated

2018-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus

Interventions

Case series:metformin

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients were diagnosed as T2DM based on 1999 WHO criteria: FPG=7.0mmol/L and/or PPG=11.1mmol/L; 2. T2DM patients received metformin hydrochloride for at least 2 days so they were at pharmacokinetic steady state; 3. All patients were unrelated.

Exclusion criteria

Exclusion criteria: 1. Patients in pregnancy or lactation period; 2. Patients with drug abuse history within a year; 3. Patients with other endocrine diseases; 4. Patients with malignant tumor; 5. Patiente taking drugs as proton pump inhibitor.

Design outcomes

Primary

Measure	Time frame
plasma drug concentration;genetype;	—

Countries

China

Contacts

Public ContactLi Yan

Shandong Provincial Qianfoshan Hospital

li_xyan@126.com+86 13791126823

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026