myocardial injury after surgery
Conditions
Interventions
Dex:dexmedetomidine treatment
NS:normal saline treatment
Sponsors
the First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Agree with the consent form; 2) Aged >= 65years old male and female; 3) Undergoing selective high-risk noncardiac surgery under general anesthesia.
Exclusion criteria
Exclusion criteria: 1)With allergic history to a2 recepter agonist or dexmedetomidine; 2) With contraindication of dexmedetomidine,such as sick sinus syndrome, severe sinus bradycardia (< 50 beats per min [bpm]), or second-degree or greater atrioventricular block without pacemaker; known allergy or hypersensitivity to dexmedetomidine; 3) serious hepatic dysfunction (Child-Pugh class C),renal dysfunction; 4) A myocardial infarction within 7 days or an ejection fraction <40% or heart failure; 5) With an expected length of hospital stay of at least 24 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of myocardial injury after noncardiac surgery;Incidence of cardiovascular adverse event; | — |
Secondary
| Measure | Time frame |
|---|---|
| other severe complications;Length of hospital stay;Incidence of 30-day readmission;Length of ICU stay;30-day mortality after surgery;1-year all-cause mortality after surgery;1-year cardiovascular mortality after surgery; | — |
Countries
China
Contacts
Public ContactFuhai Ji
the First Affiliated Hospital of Soochow University
Outcome results
None listed