bradycardia and heart block
Conditions
Interventions
Dexmedetomidine1.0ug/kg group:Dexmedetomidine1.0ug/kg load capacity
Dexmedetomidine1.5ug/kg group:Dexmedetomidine1.5ug/kg load capacity
Dexmedetomidine2.0ug/kg group:Dexmedetomidine 2.0ug/kg load capacity
Sponsors
The Affiliated Hospital of Guiyang Medical College
Eligibility
Sex/Gender
All
Age
20 Years to 30 Years
Inclusion criteria
Inclusion criteria: (1) Healthy volunteer half male and half females,age 21-30, BMI19.4-24.4 Kg/m2; (2) No long-term smoking and addicted to wine history, heart, lung, liver and kidney without abnormal, no spinal cord injury, no endocrine disease, no hyperthyroidism or hypothyroidism, no acid-base imbalance or electrolyte disturbance, no esophageal varices; (3) Neither used drugs affect the autonomic nerve nor glucocorticoid two weeks before operation.
Exclusion criteria
Exclusion criteria: (1) routine electrocardiogram show that interference ECG analysis,such as bundle branch block, left ventricular hypertrophy, atrial fibrillation or atrial flutter, high-grade atrioventricular block: long QT interval syndrome; (2) patient of central nervous system disorder, autonomic nervous system disorder; use drugs as beta-blocker or drugs affect central nervous system; (3) Person that esophagus atrial pacing electrode imbedding can not pace-making.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sinus Nodal Recover Time,SNRT;Total Recovery Time, TRT;Atrioventricular Node Wenckebach block point;Atrioventricular Node 2 : 1 block piont;Atrioventricular Node relative refractory period, AVNRRP;Atrioventricular Node effective refractory period, AVNERP; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuropetide Y, NPY;Vasoactive intestinal petide, VIP;Norepinephrine, NE;acetycholine, Ach; | — |
Contacts
Public ContactYi Zhong
Outcome results
None listed