cardiovascular
Conditions
Interventions
Group A:The doses were administered with sequence (5mg
Group B:The doses were administered with sequence (5mg
Group C:The doses were administered with sequence (15mg
10mg ) in four periods
Sponsors
The first affiliated hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
Male
Age
20 Years to 30 Years
Inclusion criteria
Inclusion criteria: (1) Healthy male and female volunteers; (2) Aged 18-40 years, with a group of subjects no younger than 10 years of age; (3) Body mass index (BMI) in the context of 19-25 kg/m2, (BMI= weight (kg)/height (m2)); (4) Vonlunteers could communicate well with the researchers and comply with the requirements of the entire study; (5) Written informed consent was obtained from all subjects prior to enrolment.
Exclusion criteria
Exclusion criteria: (1) Subjects had a history of hypersensitivity, allergy, serious adverse drug reaction, especially to penicillin drugs; (2) Participated in other clinical trials within three months; (3) Donated blood within one month, or plan to donate blood during the trial or within 1 month at the end of the trial; (4) Had received other drugs in clinical trials by vaccination or participate within nearly four weeks ; Taking any drugs within nearly four weeks; (5) Hypotension and/or a history of orthostatic hypotension; (6) Subjects had a history of Bradycardia, sinus arrest, sinoatrial block, atrioventricular block, a history of ectopic rhythm; (7) Any history of severe disease or medical history of cardiovascular system, endocrine system, nervous system, lung, hematology, immunology, pathergasiology and metabolic disturbance; (8) Any history of heart, liver, kidney, gastrointestinal tract, nervous system, metabolic disorders and other psychiatric disorders; (9) Subjects had Ocular diseases; (10) The general examination and blood pressure, heart rate and respiratory conditions did not meet with standards; (11) subjects had a history or evidence of any clinically significant diseases by direct medical history questioning and physical examination; (12) Laboratory tests (blood and urine routine, liver and kidney function, ECG and HIV et. al) found hematological abnormalities, heart, liver and kidney dysfunction; (13) Smoking, drinking or drug addiction prior to or during the study; (14) Unsuitable to participate in the trial considered by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUCtn;Cmax;Tmax;t1/2z;CLz/F;Vz/F;AUCss; | — |
Contacts
Public ContactJianzhong Shentu
Outcome results
None listed