depression
Conditions
Interventions
4:a single oral dose of 25mg agomelatine
Sponsors
the Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
Male
Age
19 Years to 29 Years
Inclusion criteria
Inclusion criteria: Aged between 18 and 40 yearsinclusive; Good general health as a result of review of medical history and/or clinical testing at the time of screening; Available for the duration of the trial (4 weeks); Willingness to participate in the study as evidenced by signing the informed consent document, or by fingerprinting the consent document with the signature of a witness.
Exclusion criteria
Exclusion criteria: Subject is unwilling to use reliable contraception methods for the period of at least 2 months prior to first adminitration to 3 months after last administration; Behavioral, cognitive, or psychiatric disease that in the opinion of the investigator affects the ability of the participant to understand and cooperate with the study protocol;Evidence of clinically significant neurologic, cardiac, pulmonary, hepatic, endocrine, rheumatologic, autoimmune, or renal disease by history, physical examination, and/or laboratory studies including urinalysis; Behavioral, cognitive, or psychiatric disease that in the opinion of the investigator affects the ability of the participant to understand and cooperate with the study protocol; Other condition that in the opinion of the investigator would jeopardize the safety or rights of a participant participating in the trial or would render the subject unable to comply with the protocol;History of receiving any investigational product within the past 30 days; History of a severe allergic reaction or anaphylaxis; subjects confirm positive hepatitis B surface antigen (HBsAg), HIV-1, hepatitis C virus (HCV).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the intra-subject coefficience of variability is 43.52%; | — |
Countries
China
Contacts
Public ContactGuoping Yang
the Third Xiangya Hospital, Central South University
Outcome results
None listed