Obesity
Conditions
Interventions
Normal-weight group :Resistant starch or control starch
Overweight or obese group:Resistant starch or control starch
Sponsors
Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Normal-weight group: Sign informed consent; Chinese; Aged between 18 to 55 years old; 18.5 kg/m2 < BMI <24 kg /m2; Waist circumference< 85 cm in men and <80 cm in women. Overweight or obese group: Sign informed consent; Chinese; Aged between 18 to 55 years old; Overweight or obesity, as defined by BMI = 24 kg/m2 or waist circumference = 85 cm in men and = 80 cm in women.
Exclusion criteria
Exclusion criteria: Normal-weight group: Known impaired glucose regulation diabetes; Known hyperthyroidism, hypothyroidism, digestive system disease, cardio-cerebrovascular disease, or any other chronic disease; Using antibiotics or probiotic supplements 3 weeks prior to the study; Regularly use of prescription drugs (regular contraceptives are excluded); Participating or have participated in other clinical trials 4 weeks before the study. Overweight or obese group: Unwilling to accept randomization Acute illness or using the antibiotics 3 weeks prior to the study; Known hyperthyroidism, hypothyroidism, diabetes, digestive system disease, cardio-cerebrovascular disease, or any other chronic disease; Current treatment with systemic corticosteroids or medications which may affect glucose metabolism; Have used antibiotics or probiotic supplements 3 weeks before the study or using during the study; Regularly use of prescription drugs (regular use of contraceptives is excluded) or Chinese and Western medicine; Participating or have participated in other clinical trials 4 weeks before the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| body weight;visceral fat area; | — |
Secondary
| Measure | Time frame |
|---|---|
| subcutaneous fat area;body fat;waist circumference;lipid profiles;insulin sensitivity;metabolome;gut microbiome; | — |
Countries
China
Contacts
Public ContactWeiping Jia
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Outcome results
None listed