not disease-related
Conditions
Interventions
Experimental:oral ingestion of a single dose of simvastatin tablets
Reference:oral ingestion of a single dose of simvastatin tablets
Sponsors
The Second Affiliated Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
Male
Age
22 Years to 25 Years
Inclusion criteria
Inclusion criteria: 1. male healthy subjects; 2. aged 18-40years; 3. Body weight (more than 50kg), BMI(19-25kg/m2); 4. without significant medical history and history of drug allergy; 5. non-drug abuser; 6. non-smokers and alcohol abuse; 7. All volunteers were not allowed to take any medications 2 wk before the study period; 8. volunteers can communicate well with investigator and obey the rules of the study; 9. All volunteers gave their written informed consent.
Exclusion criteria
Exclusion criteria: (1)subjects who paticipated in other clinical trials within the past 2 mo; (2)subjects who donated blood within the past 1 mo or will donate blood during or after the study; (3)subjects who do not pass the general physical examinations and BP, HR or breath status are not well; (4)subjects who have significant clinical symptoms by physical examination; (5)subjects who have some health problems by electrocardiogram and laboratory tests (including complete blood count, blood biochemistry testing and urinalysis) before starting this study. (6)Invesigator thinks that the subjects are not suitable for participating the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentrations of simvastatin; | — |
Countries
China
Contacts
Public ContactZou-rong Ruan
The Second Affiliated Hospital, School of Medicine, Zhejiang University
Outcome results
None listed