Cancer
Conditions
Interventions
1:Coffee enema
Sponsors
Assoc. Prof. Dr. Supanimit Teekachunhatean
Eligibility
Sex/Gender
Male
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: The healthy men, age 18-40 years (y) were enrolled in this study. The body mass index of each subject was restricted to the range of 18-25 kg/m2. All had to be in good health on the basis of medical history a physical examination. Routine blood tests including a complete blood count, a liver function test as well as a measurement of blood urea nitrogen creatinine levels were used to screen subjects in order to exclude those with abnormal hematological diseases, or abnormal liver or kidney function. All subjects had a normal blood pressure heart rate. During the screening phase subjects had to be able to retain the water enema for at least 5 min. Subjects included in the study were given detailed verbal written information regarding the nature of the study. Signed informed consent of each subject was obtained prior to the study.
Exclusion criteria
Exclusion criteria: Exclusion criteria included subjects who were not able to avoid foods or drinks that contained caffeine within the previous 10 days during the study period, as well as those with a known history of any gastrointestinal disease such as peptic ulcer, hemorrhoids, gut obstruction, diverticulitis, ulcerative colitis, Crohn’s disease, irritable bowel syndrome (IBS), colostomy, recent bowel surgery colorectal cancer. Other exclusion criteria were chronic renal, liver, neurological, pulmonary or cardiovascular diseases, recent cigarette smoking within the previous 3 months, a history of substance abuse or addiction, use of any medication within the previous month, hypersensitivity to medication in the xanthine such as theophylline or aminophylline.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bioavailability of caffeine; | — |
Contacts
Public ContactNinuch Tosri
Outcome results
None listed