Renal disease
Conditions
Interventions
citrate:citrate anticoagulation
heparin anticoagulation group:citrate anticoagulation
Sponsors
Capital Medical University Luhe Teaching Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: In ICU patients, and with acute kidney injury and/or of severe sepsis and/or of moderate and severe ARDS. Patients to be aged between 18 to 79.
Exclusion criteria
Exclusion criteria: Patients with a history of kidney disease and/or in a hemodialysis treatment; Severe hemodynamic instability; Obvious coagulopathy has to DIC state; Age less 18, or more than 79; Citrate acid can nott be metabolized efficiently because of severe hyoxemia, hepatic renal failure and muscle hypoperfusion; HIV infection; Pregnancy, organ transplantation recipient within 1 year or cachexia; Allergy of cardiopulmonary circulation, anticoagulant or blood purification equipments; Cannot undergo blood purification treatment because of other diseases or having severe complications during treatment; Cannot cooperate effectively during treatment; Involved in other clinical trails; Considered not suitable for the trail by doctors (at least 2 attendings).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| filter life loss;Coagulation parameters (APTT, PT, PLT);Acid-base parameters (PH, HCO3-, BE, AG);Adverse reaction (bleeding, allergic reaction, etc;ICU duration;Survival rate in 30d, 60d;Liver function (ALT, AST, TBIL, HBDH etc; | — |
Contacts
Public ContactWANG Guan
Outcome results
None listed