neurological complications after cardiac surgery
Conditions
Interventions
Statin Group:simvastatin
Control group:Placebo (starch tablets)
Sponsors
Sun yat-sen memorial hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1)Patients scheduled to undergo valve replacement with CBP; (2)Over 18 years old; (3)Patients signed the consent form.
Exclusion criteria
Exclusion criteria: Patients were excluded if they were unable to read or had less than a sixth grade education or had a history of symptomatic cerebrovascular disease (eg, stroke with a residual deficit), psychiatric illness (any clinical diagnoses requiring therapy), allergy to simvastatin, renal failure (serum creatinine 2 mg/dL), liver disease (liver function tests 1.5 times the upper limit of normal), higher alcohol consumption (2 drinks/d), or were during pregnancy or lactation, taking calcium-channel blockers as Mibefradil, or can't be regularly follow up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative central nervous system; | — |
Secondary
| Measure | Time frame |
|---|---|
| brain damage markers (as NSE, S100 beta);Inflammatory markers (as IL-6; IL-8; IL1 beta; IL-10; CRP);Length of ICU and hospital stay;cost of Hospitalization;30-day major adverse cardiac and cerebrovascular events; | — |
Countries
China
Contacts
Public ContactHua Ping
Outcome results
None listed