recurrent aphthous ulcer
Conditions
Interventions
treatment group:mussel adhesive protein wound dressing
control group:The sample carrier solution without mussel adhesive protein: the physiological saline solution containing 0.005% acetic acid
Sponsors
Department of Oral Medicine, Peking University School Of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Subjects volunteered for the trial and signed the informed consent; 2. 18-65 years old and sex not limited; 3. According to the clinical symptoms and signs, subjects was diagnosed with light recurrent aphthous ulcer; 4. Ulcer occurred within 48h without treatment and generally healing time was more than five days; 5. The subjects have pain discriminating ability.
Exclusion criteria
Exclusion criteria: 1. Severe systemic infection, or systemic disease; 2. There is a history of allergies or recent allergic diseases of multiple drugs; 3. Having taken antibiotics, vitamins, sedatives or other drugs in 24h; 4. Subjects have used glucocorticoid or other drugs which affect the immune function in the last three months; 5. Female in pregnancy or suckling period; 6. Subjects with a history of diseases of the immune system; 7. Subjects have used non steroidal anti-inflammatory drugs (NSAIDS) or antihistamines in one month; 8. Tumor patients; 9. Subjects have participated in the other similar products the clinical trials in one month; 10. Researchers think that subject is not suitable for the clinical trial for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ulcer pain remission rate in the day 0, day 3, day 5;The area of ulce; | — |
Secondary
| Measure | Time frame |
|---|---|
| The earliest onset time of ulcer pain remission;Pain relief time;Seepage and the degree of congestion in ulce; | — |
Countries
China
Contacts
Public ContactHua Hong
Outcome results
None listed