Research of clinical treatment system in patients with newly emerging severe acute respiratory infectious diseases

Multicenter Randomized Prospective Controlled Trial of antiviral Treatment in patients with Severe Influenza A Infection

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-14005089

Enrollment

Unknown

Registered

2014-07-20

Start date

2014-09-21

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Influenza A

Interventions

A:oseltamivir

B:peramivir

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. male or female, older than 18 years; 2. fever when screening, T higher than 38.0 degree; 3. at least one of the respiratory symptoms, for example, cough, throat, running nose/rhinobyon, with any degree (mild, moderate or severe); 4. breath shortness or dyspnea; 5. requiring hospitalization; 6. rapid antigen test of influenza A was positive; 7. the patients agreed to participate in the study and signed informed consent.

Exclusion criteria

Exclusion criteria: 1. alleged to oseltamivir or other neuraminidase inhibitors; 2. pregnancy (urine pregnancy test is positive), planned pregnancy and breast-feeding period woman; 3. ECG showed QT prolongation when screening; 4. The expected survival time was not exceeding 48 hours from the screening start; 5. The patients had tracheal intubation and mechanical ventilation when screening.

Design outcomes

Primary

Measure	Time frame
virus clearance time;Mechanical ventilation rat;	—

Secondary

Measure	Time frame
Clinical symptom improvement rate;days of hospitalization;ICU stay days;mortality;	—

Countries

China

Contacts

Public ContactWeifeng Liang

dr.liangwf@163.com+86 13957163061

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026