Would transcranial ect current stimulation (tDCS) enhance the effects of working memory training in older adults with mild neurocognitive disorder due to Alzheimers disease (AD)?

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-14005036

Enrollment

Unknown

Registered

2014-07-29

Start date

2014-11-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild Neurocognitive Disorder due to Alzheimers Disease (AD)

Interventions

Two groups:transcranial direct current stimulation and computer based working memory training four weeks versus 4 week intervention of either tDCS-working memory (DCS-WM), tDCS-control cognitive train

Eligibility

Sex/Gender

All

Age

60 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Subjects 60 to 90 years old; 2. DSM-5 diagnosis of Mild Neurocognitive Disorder due to Alzhemers disease.

Exclusion criteria

Exclusion criteria: 1. Previous diagnosis of other major neurocognitive disorders; 2. Past history of bipolar affective disorder or psychosis; 3. Physically frail affecting attendance to training sessions; 4. Already attending regular cognitive training; 5. Taking a psychotropic or other medication known to affect cognition (e.g. benzodiazepines, anti-dementia medication, etc.); 6. History of major neurological deficit including history of stroke, transient ischemic attack or traumatic brain injury, 7. Significant communicative impairments.

Design outcomes

Primary

Measure	Time frame
1. Working memory test - the n-back task performance at baseline, 4th, 8th and 12th weeks would be recorded as a direct measure of improvement in task performance.;2. Global Cognitive function would be measured by the Chinese version of the Alzheimer's disease Assessment Scale - Cognitive Subscale (ADAS-Cog).;	—

Secondary

Measure	Time frame
1. Memory and Language tests - Logical memory, 10 minutes list learning delay recall, category verbal fluency and trail making tests would also be evaluated to examine the effects of both tDCS and working memory training on other cognitive abilities;2. The Chinese Neuropsychiatric Inventory (NPI) would used to assess changes in neuropsychiatric symptoms across different 12 domains. In the current study, NPI would evaluate potential mood and behavioral change, especially mood and euphoria that may theoretically be affected by tDCS administration.;3. A checklist of potential adverse effects associated with computer based cognitive training and t-DCS administration would be generated from available literature reports. The checklist would be used to monitor tolerability and adverse events throughout intervention.;	—

Measure

Time frame

1. Memory and Language tests - Logical memory, 10 minutes list learning delay recall, category verbal fluency and trail making tests would also be evaluated to examine the effects of both tDCS and working memory training on other cognitive abilities;2. The Chinese Neuropsychiatric Inventory (NPI) would used to assess changes in neuropsychiatric symptoms across different 12 domains. In the current study, NPI would evaluate potential mood and behavioral change, especially mood and euphoria that may theoretically be affected by tDCS administration.;3. A checklist of potential adverse effects associated with computer based cognitive training and t-DCS administration would be generated from available literature reports. The checklist would be used to monitor tolerability and adverse events throughout intervention.;

—

Countries

China

Contacts

Public ContactLinda CW Lam

cwlam@cuhk.edu.hk+852 26076027

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 15, 2026