Type 2 Diabetes
Conditions
Interventions
Usual Care Group:Acarbose+routine diet guidence for diabetes patients
WTP Diet Group:Acarbose+whole grains, traditional Chinese medicinal foods and prebiotics diet
Sponsors
Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed T2DM patients according to ADA standards 2012 whose HbA1c is between 6.5% and 12.0%; 2. Aged 35-70 year old; 3. Han people living in the local more than five years and having constant residence; 4. Having not attend any other research projects; 5. Having good memory and motility; 6. Having healty mentality and self-care ability; 7. Providing written informed consent and others; 8. Having good compliance: no business trips, no outdoor dining, regular work and rest time, having a buring desire to change his physical condition.
Exclusion criteria
Exclusion criteria: 1. More than one of diabetes antibodies (IAA, ICA and GAD) was detected as positive and the patient was diagnosed as type 1 diabetes; 2. With severe diabetes complications, e.g. leg ulcers, severe liver and kidney damage, severe neurological diseases and severe retinopathy; 3. Antibiotic or weight-loss drugs usage continuously for more than 1 month; 4. Pregnancy or planning to become pregnant; 5. Intemperance(drinking more than 5 times in one week and drinking more than 100g spirit, 250g ricewine or 5 bottles of beer); 6. With severe mental disease in last 6 months; 7. Received drug therapy aim at the following diseases, e.g. cholecystitis, peptic ulcer, urinary tract infection, acute pyelonephritis, urocystitis or hyperthyreosis; 8. Received gastrointestinal surgery except for appendicitis or hernia surgery; 9. With chronic persistant hepatitis, severe hepatic diseases, e.g. liver cirrhosis or cooccurence of positive HBsAg and abnormal hepatic transaminase; 10. With IBD or Cushing's syndrome; 11. With pituitary dysfunction; 12. With severe organic disease, e.g. cancer,coronary heart disease, myocardial infarction and cerebral apoplexy; 13. With infectious disease, e.g. phthisis and Aids; 14. Physical Disability or self-care disability or disability of recalling clearly and answering questions caused by any other reasons; 15. Slimmer using any weight loss drugs or surgical methods in last 3 months; 16. With obvious dyskinesia; 17. Without enough time taking part in this project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1c; | — |
Secondary
| Measure | Time frame |
|---|---|
| OGTT Glucose;OGTT Insulin;HOMA-IR index;HOMA-beta Index;Glycated Serum Protein;Cholesterol;Triglyceride;Low Density Lipoprotein;High Density Lipoprotein;Weight;Body Mass Index;Waistline;Hipline;Body Fat Distribution;Blood Pressure;CEA;Drug Usage;Intestines secrete peptid;Gut microbiota function;The metabolism of gut microbiota;The compositioin of gut microbiota; | — |
Countries
China
Contacts
Public ContactLiping Zhao
Outcome results
None listed