Adolescent Idiopathic Scoliosis
Conditions
Interventions
A:Enriched Allogeneic Bone
B:Allogeneic Bone
Sponsors
Department of Orthopaedics, Southwest Hospital, the Third Military Medical University
Eligibility
Sex/Gender
All
Age
10 Years to 20 Years
Inclusion criteria
Inclusion criteria: 1. Patients with scoliosis and spinal deformity (Cobb angle more than 45 degree, Lenke grade I-III) with serious impact on the beauty but with good spinal flexibility, or those with deformity progressing rapidly in a short time, sharply limited pulmonary function due to thoracic deformity and affected daily activity; 2. Age 10-20, all genders; 3. Patients without any contraindication to bone marrow extraction, such as blood system diseases (e.g., coagulation disturbance), infection at venipuncture sites, serious immunosuppression or allergic constitution.
Exclusion criteria
Exclusion criteria: 1. Age: younger than 10 or older than 20; 2. Patients with spinal stiffness complicated with razor-like back, with rib resection required and Lenke grade IV-VI; 3. Patients with operative contraindications caused by other accompanying diseases, such as serious respiratory, cardia-cerebrovascular, digestive, endocrine and urinary diseases; 4. Psychopaths, pregnant women, and those with bad addictions (e.g., drugs and alcohol); 5. Patients involved in other trials simultaneously or just finished other trials; 6. Patients with contraindications to bone marrow extraction, such as blood system diseases (e.g., coagulation disturbance), infection at venipuncture sites, serious immunosuppression and allergic constitution.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analog Scale;Oswestry Disability Index;RS30 scoliosis scale;Coronal and sagittal parameters;Percentage of bone fusion;Osteogenic quality scale;Evaluation and calculation of osteogenesis volume;Bone fusion tim; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lenke classification;Operation time;Volume of bleeding in surgery;Postoperative hospital stay; | — |
Contacts
Public ContactTianyong Hou
Outcome results
None listed