Analysis of curative effect of intracranial infections after craniotomy treated with intraventricular combined with intracenous vancomycin versus simple intracenous injection

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-14004945

Enrollment

Unknown

Registered

2014-07-13

Start date

2014-07-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intracranial infections after craniotomy

Interventions

2:vancomycin 1 gram q8h + meropenem 2 gram q8h

Routine + local injection:vancomycin 1 gram q8h and 10 mg local injection + meropenem 2 gram q8h

Reducing dose + local injection:vancomycin 1 gram q12h and 10 mg local injection + meropenem 2 gram q8h

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. after craniotomy neurosurgery, diagnosis of intracranial infection; 2. ages 18 to 65 years; 3. have lien ventricle drainage tube.

Exclusion criteria

Exclusion criteria: 1. a history of vancomycin and/or meropenemfor allergies; 2. serious heart, lungs, liver, kidney and other organs disfunction; 3. maternal in the perinatal period.

Design outcomes

Primary

Measure	Time frame
The course of vancomycin treatment in the CSF cultures G + bacteria;	—

Countries

China

Contacts

Public ContactWang Qiang

ttyywq@163.com+86 10 67096518

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026