depression disorder
Conditions
Interventions
ketamine:receive a single intravenous infusion of Ketamine+oral Escitalopram Oxalate Tablets 10mg/d four weeks
control group:receive a single intravenous infusion of 0.9% saline + +oral Escitalopram Oxalate Tablets 10mg/d four weeks
Sponsors
Beijing Chaoyang Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria were: 1. age 18-60 years; 2. both genders; 3. diagnosis of non-psychotic major depression established by treating psychiatrists and confirmed by a checklist based on DSM-IV criteria at study entry; 4. total score of the 17-item Hamilton Rating Scale for Depression (HAMD)–Chinese version >/=24 and a score of the item 3 on suicide risk >/=1; 5. ability to communicate and provide written consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria included: (1) lifetime history of drug/alcohol dependence, psychotic, bipolar or obsessive-compulsive disorders; (2) any Axis I disorder other than major depression judged to be the primary presenting problem; (3) history of inefficacy or intolerance toescitalopram; (4) Pregnant or breast-feeding; (5) suicide attempt in the current episode; (6) major medical conditions contraindicating the use of ketamine and/orescitalopram; or (7) ECT or NMDA antagonist medicationsadministered within the past 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montgomery-Asberg depression rating scale;16-item Quick Inventory of Depressive Symptomatolo; | — |
Secondary
| Measure | Time frame |
|---|---|
| the Clinician Administered Dissociative States Scale, CADSS;A checklist with the common somatic side effects; | — |
Countries
China
Contacts
Public ContactYD Hu
Outcome results
None listed