Anti-NMDA receptor encephalitis
Conditions
Interventions
1:hormone and plasmapheresis
2:hormone and intravenous immunoglobin
Sponsors
Xuanwu Hospital of Capital Medical University, Beijing, China
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic standard of anti-NMDA receptor encephalitis: Any age, especially less than 50 years old; clinical manifestations including rapid mental and behavioral abnormality, memory disorder, language disorder, epilepsy, involuntary movements, disturbance of consciousness, autonomic nerve dysfunction and central hypoventilation; anti-NMDA receptor antibody of cerebrospinal fluid positive accompany with or without anti-NMDA receptor antibody of serum positive; exclude other diagnoses, such as viral encephalitis, brain tumors, metabolic disorders, drug poisoning and so on; 2. Within 1 month after onset; 3. Diagnosis for the first time and with the initial treatment; 4. Sign informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1. With severe basic diseases, such as heart failure, arrhythmia, blood coagulation dysfunction; 2. With past history of immunoglobin allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| modified Rankin Scale;NMDA receptor antibody in CS; | — |
Secondary
| Measure | Time frame |
|---|---|
| NMDA receptor antibody in plasm; | — |
Countries
China
Contacts
Public ContactSu Yingying
Outcome results
None listed