Tuberculosis
Conditions
Interventions
The test group:Silibinin capsule + anti tuberculosis drugs
Control group:anti tuberculosis drugs only
Sponsors
Tongji University Affiliated Hospital of Shanghai City
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18~65 years male or female; 2. pulmonary tuberculosis cases, released in January 16, 2008,with the Ministry of health; 3. Before treatment were not used anti tuberculosis drugs; 4. Before treatment, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AKP) and total bilirubin (TBiL), direct bilirubin (DBiL) were within the normal range.
Exclusion criteria
Exclusion criteria: 1. Patients with liver diseases (such as alcoholic liver disease, autoimmune liver disease, liver disease, with active hepatitis B and C); 2. Serious heart, brain, kidney, gastrointestinal disorders and systemic system; 3. HIV infection; 4. At the same time, the application effect of the drug efficacy; 5. Study on drug allergy or intolerance; 6. Patients have no ability to express their complaints, such as psychosis and neurosis are serious; 7. Poor compliance are not cooperation; 8. Pregnant and lactating women, or women preparing for pregnancy; 9. Other clinical researchers in 3 months; 10. Study physicians believe not suitable situation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ALT;AST;AKP;TBiL;DBiL;TP;ALB;TB in Sputum smear;TB in Sputum culture;Abdominal B Ultrasoun; | — |
Secondary
| Measure | Time frame |
|---|---|
| WBC;Neutrophil count;Lymphocyte count;Eosinophil count;Hb;PLT;Urinary RBC;Urinary WBC;Urinary PRO;X-ray film; | — |
Countries
China
Contacts
Public ContactHeping Xiao
Tongji University Affiliated Hospital of Shanghai City
Outcome results
None listed