Hyperalgesia
Conditions
Interventions
contorl:Normal saline is intravenously administrated before anesthesia induction
Dexmedetomidine group (Dex):Dexmedetomidine is intravenously administrated at a dose of 1.0µg/ kg at 10 min intervals before anesthesia induction, remifentanil maintenance at a dose of 0.3µg/kg·min
Flurbiprofen axetil group I:Flurbiprofen axetil is intravenously administrated at a dose of 1.5mg/ kg before anesthesia induction, remifentanil maintenance at a dose of 0.3µg/kg.min
Flurbiprofen axetil group II (Flu II):Flurbiprofen axetil is intravenously administrated at a dose of 1.5mg/ kg before 15 minutes completion of surgery, remifentanil maintenance at a dose of 0.3µg·kg·
Dexmedetomidine combined Flurbiprofen axetil group:Dexmedetomidine is intravenously administrated at a dose of 1.0µg/ kg at 10 min intervals and Flurbiprofen axetil is intravenously administrated at a
Dexmedetomidine combined Flurbiprofen axetil group:Dexmedetomidine is intravenously administrated at a dose of 1.0µg/ kg at 10 min intervals before anesthesia induction, and Flurbiprofen axetil is int
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Upon approval of the ethics committee at our hospital, the patients or their family members have signed informed consent. ASA I - II class undergoing elective surgery patients, 180 cases of laparoscopic cholecystectomy, aged 18 to 60. There is no history of using long-term opioid drugs and narcotics.
Exclusion criteria
Exclusion criteria: Dexmedetomidine and flurbiprofen axetil allergies, clinical severe liver and kidney disease or mental illness, pregnant woman, with alcohol or drug abuse ,history of using containing ingredients of opioid analgesic or sedative ,any contraindication for the use of patient-controlled analgesia (PCA).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain threshold;Cumulative sufentanyl consumption; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visul Analog Scale;Time of first postoperative analgesic requiremen; | — |
Contacts
Public ContactShiyuan XU
The Department of Anesthesiology, Nanfang Hospital
Outcome results
None listed