Knee Osteoarthritis
Conditions
Interventions
pulsed radiofrequency treatment group:pulsed radiofrequency treatment
Sponsors
Huadong Hospital, Shanghai Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. All subjects meet diagnostic criteria derived from the American rheumatism association (ACR), aged from 18 to 75 years old male and female: (1) Repeated pain in knee for almost a month; (2) X ray film suggested osteophyte has formed; (3) Fulfil one of the following conditions: morning stiffness within 30 min, joints have rubs in motion, aged from 18 to 75 years. And satisfy: 1) Repeated pain in knee for almost a month; 2) X ray film suggested osteophyte has formed; 3) Without receiving drug therapy within two weeks; 4) ruled out the subjects with active gastrointestinal tract, gastrointestinal ulcers in a year, cardiac insufficiency, kidney, liver disease or blood coagulation dysfunction and diagnosised with infectious arthritis, gout or acute Knee Osteoarthritis injured; 5) Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Subjects did not follow the scheduled treatment, unable to determine the efficacy or the data is not complete, and these factors will have an effect on the evaluation of treatment effect; 2. Subjects who are receiving other treatments, and the treatments will affect the index observation of study effects; 3. Subjects participated in other drug clinical trials within four weeks; 4. Subjects accompanied with life-threatening primary disease derived from cardio-cerebrovascular, liver, kidney and hematopoietic system and mental patients, etc.; 5. excluding the subjects with NSAID allergy history; 6. Pregnant and nursing women; 7. Subjects, with poor compliance for the research procedure, cannot finish the research plan, including dysphasia, infectious diseases and other medical history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| tender point Visual Analogue Scale;WOMAC scale;Lysholm Knee Osteoarthritis Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lequesne pain scale;knee join movement degrees;6 minutes walk test;Climb the stairs;MOS sleep quality scale;high sensitivity CRP;osteocalcin;inflammatory factor; | — |
Contacts
Public ContactYongjun Zheng
Huadong Hospital, Shanghai Fudan University
Outcome results
None listed