Gastroesophageal Reflux Disease
Conditions
Interventions
Group A:Endoscopic Cardia Ligation and clip
Group B:Proton Pump Inhibitor 20mg, Bid
Sponsors
Digestive Endoscopic Centre, Department of Gastroenterology and Hepatology. The Chinese PLA General Hospital.
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Clinical diagnosed as GERD by an physician with clinical symptoms, 24-hour Esophageal pH Monitoring diagnose (Demeester score>30.0) and symptoms not relief or recurrent attacks after medical treatment over 2 months, sign informed consent.
Exclusion criteria
Exclusion criteria: Patients whose biopsy confirmed as Barrett or early esophageal cancer; who had received surgical operation such as gastric plication and normal anatomic structure has been destroyed whose hiatal diameter is over 3cm.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptom remission rate;24-hour Esophageal pH Monitoring;Endoscopic findings (Cardiac relaxation and Change of gastric fundus);GERD Q Score;Long-term complications;phageal Motility Changes; | — |
Secondary
| Measure | Time frame |
|---|---|
| The recurrence rate;Change of body weight; | — |
Countries
China
Contacts
Public ContactLINGHU En-qiang
Digestive Endoscopic Centre, Department of Gastroenterology and Hepatology. The Chinese PLA General Hospital.
Outcome results
None listed