Asthma
Conditions
Interventions
high-dose group/regular-dose group:budesonide versus formoterol(160/4.5ug)
Sponsors
First Affiliated Hospital of Guangzhou Medical University, Guangdong 510012,China
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients' state at the admission should be in line with the diagnostic criteria of moderate-severe asthma recommended by GINA Guideline in 2010. In 2 weeks before the admission, the enrolled patients did not use systemic corticosteroids (including oral and injectable steroid hormones, with an equivalent dose less than prednisone (10mg)). However, the usage of ICS or ICS+LABA could be used, associated or not associated by a history of SABA treatment. The dose was not strictly required.The admission criteria of moderate-severe asthma mainly included daytime symptoms, nocturnal symptoms and pulmonary function testing indicators. The latter mainly included the percentage of forced expiratory volume in 1s in the predicted value (FEV1% pred) and the aberration rate of peak expiratory flow (PEF). The specific indicators included: daytime symptoms >= once per day, and the onset influenced activity or limited physical activity; nocturnal symptoms >=once per week even frequent attacks during the night, and the onset influenced the sleep; pulmonary function indicators were consistent with 80%>FEV1%pred>=30% or the aberration rate of PEF >30%.
Exclusion criteria
Exclusion criteria: Exclude other combined history of disease (except hypertension), and no ß receptor antagonist
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LUNG function; | — |
Countries
China
Contacts
Public ContactChunrong JU
First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed