Atrial fibrillation, Deep vein thrombosis
Conditions
Interventions
Two groups:Two different doses courses according to algorithm
Sponsors
the Third Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: Patients of both sexes, aged 60 years or older, diagnosed with AF or DVT requiring warfarin therapy with a target INR in the lower intensity range (1.5-2.5) for at least 8 weeks are eligile for the trial. They should have the ability to make good communication with researchs and complete the study.
Exclusion criteria
Exclusion criteria: Patients will be excluded from the trial if they have known their CYP2C9 or VKORC1 genotype, if they have treated with a coumarin derivative previously, if thier baseline INR of 1.5 and higher, if they have higher risk of blood, if their hemoglobin less than 1000g/L or platelet count less than 75×10^9/L or total number of white blood cell (WBC) less than 3×10^9/L, if they suffer from severe cognitive impairment, or if they have other clinical reasons that clinical doctors judged.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the percentage of time in therapeutic INR range; | — |
Countries
China
Contacts
Public ContactGuoping Yang
the Third Xiangya Hospital, Central South University
Outcome results
None listed