Mitral regurgitation
Conditions
Interventions
Sponsors
Division of Cardiology Department of Medicine and Therapeutics The Chinese University of Hong Kong
Eligibility
Sex/Gender
Male
Age
18 Years to 999 Years
Inclusion criteria
Inclusion criteria: 1. MVP which is defined echocardiographically as more than 2mm displacement of the mitral leaflets into the left atrium beyond the annulus plane in parasternal long-axis view during systole, and 2. Clinical indication for TEE including evaluation of regurgitation severity, assessment of mitral valve repairability, preoperative evaluation, non-diagnostic transthoracic images, exclusion of endocarditis, and evaluation of cardiac source of embolic event. - The proximal isovelocity surface area method will be used to quantify the effective regurgitant orifice (ERO) (32), with flow constraint corrected for the angle with the adjacent walls in cases where the regurgitation convergence is eccentric. Patients will be divided into 2 groups according to MR severity. The MVP-MR+ group with MR =3+ (ERO =0.3cm^2) and the MVP-MR- group with MR=2+ (ERO =0.29 cm^2). Ruptured chordae tendinae and flail leaflet will be diagnosed by combined information obtained by 2D/3D echocardiography as previously described (16). - Normal reference group: Patients who are referred for TEE and found to have no underlying cardiac abnormality or rhythm disturbance will be recruited. - Non-prolapse organic MR group: Patients who have moderate or severe organic MR due to non-prolapse pathology as a reference group to ascertain any abnormality in ventriculo-annular interaction is not secondary to MR per se.
Exclusion criteria
Exclusion criteria: Mitral stenosis -Aortic valve disease -Congenital or pericardial diseases -Endocarditis -Cardiomyopathy -Pregnancy -Age<18y -Contraindications to TEE
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Early systolic rate of change of MA geometry Singl; | — |
Countries
China
Contacts
Public ContactProf.Alex Pui Wai LEE
Outcome results
None listed