Chronic obstructive pulmonary disease
Conditions
Interventions
one:Tiotropium 18ug o.d. / Fluticasone 500ug b.i.d
two:Tiotropium 18ug o.d.
Sponsors
Respiratory Department, the Second Affiliated Hospital of Third Military Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged at least 40-year-old adult male or female patients, who have signed an informed consent form prior to initiation of any study-related procedure; 2. Diagnosed COPD (According to 2013 GOLD strategy); 3. At least 2 moderate COPD exacerbation or 1 COPD exacerbation required hospitalization or post-bronchodilator FEV1%< 50% in the previous 12 month.
Exclusion criteria
Exclusion criteria: 1. Patients required treatment with systemic corticosteroids in the 3 month prior to Visit 1; 2. Patients required treatment with antibiotics in the 3 month prior to Visit 1; 3. Patients with clinically significant bronchiectasis; 4. Patients with active pulmonary tuberculosis; 5. Patients unable to use a dry powder inhaler device or Metered Dose Inhaler (MDI).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference between the two treatment groups in 12 week treatment of airway colonization bacteria abundance; | — |
Countries
China
Contacts
Public ContactQiao Zhang ,Qianli Ma
Respiratory Department, the Second Affiliated Hospital of Third Military Medical University, Chongqing
Outcome results
None listed