Acute Ischemic Stroke
Conditions
Interventions
Chinese hebral group:Xiaoxuming Decoction
Placebo group:Placebo
Sponsors
Zhongshan Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Who are in accordance with the criteria of acute cerebral infarction of "2010 China guidelines for diagnosis and treatment of acute ischemic stroke" 2. Who have the characteristics of wind, fire, stasis syndromes of TCM according to "the diagnostic scales for syndrome factors of ischemia stroke"; 3. Onset of acute cerebral infarction =72 hours; 4. NIHSS 4 to 21, and; 5. GCS = 7; 6. It is the first attack; or there is stroke history, but no serious disability, and mRS = 1; 7. Male and female aged 40 to 80 years; 8. to be voluntarily join the tial and have signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Who have bleeding or other pathological brain diseases, such as vascular malformations, tumors, abscesses or other common non-ischemic cerebral diseases (e.g., multiple sclerosis), according to baseline CT or MRI; 2. Who had thrombolysis or endovascular treatment; 3. Who are allergic to any ingredients of the test herbs; 4. If having diabetes, who have complicated by dysfunction of central nerve system, peripheral neuropathy or gangrene; 5. For people having severe damage on liver function, whoes ALT or AST levels are 1.5 times higher than normal value; 6. For people having severe renal dysfunction, whoes serum creatinine is 1.5 times higher than normal value; 7. For people having severe heart failure, the ultrasonic cardiography displays more than grade III cardiac dysfunction; 8. Who have brain tumor, brain trauma, cerebral parasitic disease, and cerebral thrombosis caused by rheumatic heart disease, coronary heart disease and other heart disease with atrial fibrillation; 9. Who have severe stroke sequelae and mRS = 2; 10. Disability prohibited by law (such as blind, deaf, dumb, mental retardation, mental disorders)and limb disability caused by other reasons, which affect the evaluation of nervous function; 11. Who have bleeding tendency or severe hemorrhage occurred within 3 months; 12. Who have been suspected alcohol or drug abuse, or other conditons which reduced the possibility or increased the complex to join the trail according to the researcher's judgment; 13. Who are pregnant or lactating women, or have positive pregnancy test or recent fertility plan; 14. Who are participating in other clinical trials or have participated in other clinical trials within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Barthel Index;NIHSS; | — |
Countries
China
Contacts
Public ContactLi Wen-wei
Zhongshan Hospital of Fudan University
Outcome results
None listed