Nasopharyngeal carcinoma
Conditions
Interventions
2:Cisplatin chrono-chemotherapy concurrent with intensity-modulated radiation therapy
1:Induction chemotherapy followed by cisplatin conventional chemotherapy concurrent combined with intensity-modulated radiation therapy
Sponsors
Guizhou Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. The pathological diagnosis of early cure III-IV stage of patients with advanced nasopharyngeal carcinoma (according to the 2010 UICC staging criteria, T3-4, N0-3), no evidence of distant metastasis (M0). Have a measurable tumor lesions; 2. Karnofsky score=70; 3. Aged 18-70 years old, male or female; 4. No major organ dysfunction; Normal bone marrow hematopoietic function (white blood cell =4.0×10^9/L; Platelet=100×10^9/L; Hemoglobin =100g/L) normal liver function (total bilirubinalanine aminotransferase aspartate aminotransferase =1.5 times the upper limit of normal)normal renal function (creatinine =1.5 times the upper limit of normal) electrocardiogram does not affect the normal treatment; 5. To understand this study and sign informed consent form.
Exclusion criteria
Exclusion criteria: 1. A distant metastasis; 2. Patients with physical or mental illness, and researchers think that patients can't fully or adequately understand the possible complications of this study; 3. Pregnancy (confirmed by serum or urine ß-HCG test) or between lactation period; 4. Serious complications, such as uncontrollable hypertension, heart function failure, diabetes, etc.; 5. Who had received radiation and chemotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Toxicity;Curative effect; | — |
Countries
China
Contacts
Public ContactFeng Jin
The Affiliated Hospital of Guiyang Medical College/The Affiliated Cancer Hospital of Guiyang Medical College/Guizhou Cancer Hospital
Outcome results
None listed