Pancreatic Cancer
Conditions
Interventions
test group:microbubble cavitation by local diagnostic ultrasound irritation
Sponsors
Department of Ultrasound, the Second Affiliated Hospital of Third Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Histologically or cytologically confirmed locally advanced pancreatic cancer patient; 2. Aged 18-75 years old, male or female; 3. Have a measurable tumor lesion for oncology assessment (ultrasound, CT or MRI); 4. Expected survival of three months or more, PS score 0-2; 5. WBC=3.5×10*9/L; ANC=1.5×10*9/L; PLT=80×10*9/L; Hb=90/L; 6. Normal liver and kidney function; ALT, AST = 2.5 times upper limit of normal; Urea, Cr = 1.25 times upper limit of normal; ALT, AST = 5 times upper limit of normal for patients with liver metastases; 7. Normal heart and lung function; 8. No history of other malignant tumors; 9. Good compliance, no mental disorder; 10. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Do not meet the inclusion criteria; 2. Pregnancy or breast-feeding; 3. Allergy or hypersensitive to chemotherapy drugs; 4. With obstruction or incomplete intestinal obstruction; 5. With massive ascites; 6. With brain or bone metastasis; 7. Receiving other anti-cancer drugs or radiation therapy; 8. Participating in other clinical trials or end time is less than four weeks of chemotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective response rate;Progress free survival;Time to symptom progress; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival; | — |
Contacts
Public ContactLiu Zheng
Department of ultrasound, Xinqiao Hospital,
Outcome results
None listed