refractory status epilepticus
Conditions
Interventions
intervention group:hypothermia
intervention group:intravenous anesthetic
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
14 Years to 75 Years
Inclusion criteria
Inclusion criteria: All patients were 14 years or older (patients aged less than 14 years is admitted to pediatrics clinics in China); RSE is defined as either clinical or electrographic seizures after receiving adequate doses of an initial benzodiazepine followed by a second acceptable antiepileptic drug (AED).
Exclusion criteria
Exclusion criteria: 1. Unstable vital signs, such as a pulse of 34.2µmol/L, Cr>104µmol/L), Coagulation disorders(platelets1.3, APTT>1.53*upper limit of normal range, Fib<2g/L); 3. Pregnancy; 4. contraindication of anesthetics: such as schizophrenia, depressive state, myasthenia gravis, allergy to benzodiazepines and so on.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical and(or) EEG termination of seizures;decrease of seizures;recurrence;mortality at 3 months;GOS score at 3 months;circulation inhibition;post-SE symptomatic epilepsy at 3 month; | — |
Secondary
| Measure | Time frame |
|---|---|
| liver dysfunction;kidney dysfunction;EEG patterns before hypothermia;EEG patterns after hypothermia;duration in NICU;duration of hospitalization; | — |
Countries
China
Contacts
Public ContactSu Yingying
Xuanwu Hospital, Capital Medical University
Outcome results
None listed