Elective surgery with potential massive blood loss requiring blood transfusion
Conditions
Interventions
Three groups:1. transfusion to keep Hb more than 10g/dL , 2. transfusion based on clinicians' discretion when Hb between 7-10g/dL
and 3. POTTS group, during Intra-operative and post-operative period
Sponsors
Prince of Wales Hospital, Shatin, Hong Kong
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age older than 14 weeks old; 2. Live in an area of altitude shorter than 2500 m most of the time; 3. Estimated intraoperative blood loss more than 1000ml, or more than 20% of total blood volume.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Patients with physical status of ASA class V or above; 3. Patients with known severe haematological disorders; 4. Patients with known haemaglobinopathy; 5. Acute hypervolemic haemodilution is planned; 6. Patients with known metastatic cancer or more than one neoplasm concurrently; 7. Other conditions that may preclude the patients from the study, such as language barrier, psychiatric disorders, unable to attend research center for follow up; 8. Patients who enrolled to another research study or are taking experimental medication in last 3 months prior to this study; 9. Not suitable for the study, after assessment by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1 Incidence of patients required blood transfusion and the unit number of blood transfused.;2 Mortality rate and incidence of serious complications.;3 Five-year in remission survival rate after hospital discharge and overall survival rate.; | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Intensive Care Unit (ICU) admission rate and ICU length of stay (LOS);;2. Post-operative Hb level;;3. Surgical wound complication rate;;4. Hospital length of stay;;5. Transfusion-related cost and hospital admission cost;;6. Post-operative quality of life.; | — |
Countries
China
Contacts
Public ContactMs Winnie Samy
Outcome results
None listed