Knee Osteoarthritis
Conditions
Interventions
Two groups:To compare the blood-saving effects and risks of developing symptomatic thromboembolic events after total knee arthroplasty by using intra-articular and intravenous tranexamic acid
Sponsors
Dr KY Chung
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusive criteria are subjects with degenerative osteoarthritis of knee joints, who are scheduled for TKA with posterior stabilized total knee prosthesis.
Exclusion criteria
Exclusion criteria: Exclusion criteria are patients with pre-operative anemia with haemoglobin level less than 12 g/dL (reference of PWH lab), known allergy to TNA, deep vein thrombosis, pulmonary embolism, ischemic stroke, those on anticoagulant drugs including warfarin and Plavix, or those undergo TKA under epidural anesthesia, those with renal impairment(with creatinine level >200) and inflammatory arthritic patient.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood loss after operation, based on the change in haemoglobin level, drain output and wound discharge at baseline and post-operation day 5;any symptomatic thromboembolic events after operation at post-operation day 5; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of stay in hospital; | — |
Countries
China
Contacts
Public ContactDr KY Chung
Outcome results
None listed