major abdominal surgery
Conditions
Interventions
Experimental group:dexmedetomidine
Control group:normal saline
Sponsors
First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. patients scheduled for major abdominal surgery; 2. Patients of ASA I-II; 3. Signed and dated written informed consent obtained from the subject and/or subject's legally acceptable representative prior to study participation.
Exclusion criteria
Exclusion criteria: Patients with abnormal electrocardiogram or chest X-ray, cardiac or pulmonary insufficiency, diabetes, body mass index >30 kg/m2, allergic history, history of drug abuse and infusion liquid contain glucose within 6 hours before operation,underwent urgent/emergency surgery were excluded. Patients who had severe complications such as cardiovascular events, allergic shock, intraperitoneal hemorrhage or application of insulin after operation were also excluded.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Tumor necrosis factor a;interleukin-4;interleukin-10;C-reactive protein; | — |
Primary
| Measure | Time frame |
|---|---|
| interleukin-6;fasting plasma glucose;Insulin; | — |
Countries
China
Contacts
Public ContactFan Zhang
Department of Anesthesiology, the First People's Hospital of Jiashan County
Outcome results
None listed