Cognitive Dyfunction after Cardiopulmonary Bypass in Cardiac Surgical Patients
Conditions
Interventions
Shenmai injection group:After induction, SMI with a dose of 0.6 mL/kg dissolved in 250 mL of normal saline was administered intravenously before CPB at the speed of 10 mL/min
Sponsors
The First Affiliated Hospital of Wenzhou Medical
Eligibility
Sex/Gender
All
Age
40 Years to 69 Years
Inclusion criteria
Inclusion criteria: Forty patients scheduled for cardiac surgery with CPB were selected. Enrollment criteria included American Society of Anesthesiologists (ASA) physical status II–III, aged 40 years to 69 years, body mass index 18 kg/m2 to 29kg/m2, left ventricular ejection fraction=0.3, the Beijing version of the Montreal Cognitive Assessment (MoCA –BJ) scores=26.
Exclusion criteria
Exclusion criteria: Patients with known diabetes mellitus, hypertension, peripheral vascular disease, pulmonary disease, neurological disease, mental disorder, renal insufficiency, liver dysfunction, infective endocarditis or previous coronary heart disease were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuroglobin;Neuron-Specific Enolase;Hypoxia-Inducible Factor-1a;Montreal Cognitive Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| jugular venous oxygen saturation;jugular venous oxygen partial pressure; | — |
Countries
China
Contacts
Public ContactLINA LIN
Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical College
Outcome results
None listed