knee osteoarthritis
Conditions
Interventions
Celebrex group:Oral Celebrex
Sodium hyaluronate group:intra-articular injections of Sodium hyaluronate
PRP group:ultrasound-guided intra-articular injections of platelet-rich plasma
Sponsors
Zhejiang Provincial Hospital of TCM
Eligibility
Sex/Gender
All
Age
35 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged 40-75 years old; 2. chronic joint pain or swelling (longer than 6 months); 3. X-ray or MRI suggestive of knee degeneration performance; 4. Kellgren-Lawrence (K-L) grade 0-II levels: 0: normal; Level I: joint space narrowing may be possible osteophytes; II: There is a significant osteophytes, joint space narrowing suspiciously.
Exclusion criteria
Exclusion criteria: Relative contraindications: 1. diabetes, blood diseases, severe cardiovascular disease, infections, a history of recurrent ulceration / bleeding history; 2. taking anticoagulants and immunosuppressive agents within three months; 3. hemoglobin less than 11g/L, platelets less than 1.5*10^5/L. Absolute contraindications: 1. pregnant and lactating women; 2. known for Celebrex, sodium hyaluronate allergic patients; 3. patients with active peptic ulcer/bleeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI; | — |
Countries
China
Contacts
Public ContactTong Peijian
First Clinical Medical College of Zhejiang Chinese Medical University
Outcome results
None listed