Effect of the Rational Administration on postoperative Pain and Inflammatory Reaction

Administration according to Flurbiprofen Axetil Pharmacokinetics Reduces Sufentanil Consumption and Regulats Postoperative Cytokine Response in Colorectal Cancer Surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-14004342

Enrollment

Unknown

Registered

2014-03-06

Start date

2014-03-04

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain and inflammatory response after colorectal cancer resection

Interventions

two groups:Administration according to Flurbiprofen Axetil Pharmacokinetics

Eligibility

Sex/Gender

All

Age

30 Years to 70 Years

Inclusion criteria

Inclusion criteria: ASA physical status I/II patients, aged 30–70 yr, scheduled for elective CRC surgery were included, the type of surgery: 1. Hemicolectomy (left); 2. Hemicolectomy (right); 3. Sigmoid colectomy; 4. Miles; 5. Dixon

Exclusion criteria

Exclusion criteria: 1) patients who had received NSAIDs, opioid or other analgesic in the 24 hr before surgery; 2) patients with a history of allergic reaction to opioid and NSAIDs; 3) patients with any contraindications for the use of NSAIDs, such as gastrointestinal ulcer, coagulation disorders, renal dysfunction, heart failure and ischemic heart disease; 4) patients with preoperative hemoglobin<100g/L and perioperative blood transfusion.

Design outcomes

Primary

Measure	Time frame
visual analogue scale;bruggman comfort scale;Sufentanil Consumption;Cytokin;	—

Countries

China

Contacts

Public ContactRuiqin Zhang

Second Hospital of Harbin Medical University

zhangruiqin2003@126.com+86 13796065822

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026