severe Mycoplasma pneumoniae pneumonia in children
Conditions
Interventions
Group 1:methylprednisolone 2mg/Kg
group 2:methylprednisolone 10mg/Kg
Sponsors
Beijing Children's Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 5 Years
Inclusion criteria
Inclusion criteria: Mycoplasma pneumoniae pneumonia diagnosis criteria were based on the "Zhu Futang Practical Pediatrics" (Seventh Edition): (1) have a fever>38.5 degree C; (2) increased respiratory rate(infant>70/minelder children>50/min); (3) dyspnea; (4) cyonosis; (5) Multi lobe involvement or = 2/3 lung involvement; (6) ultrapulmonary complication; (7) pleural effussion; (8) Transcutaneous oxygen saturation =92%; (9) Macrolide antibiotics in the treatment of 1 weeks is invalid. Subjects were informed and understand the adverse reactions.
Exclusion criteria
Exclusion criteria: 1. common sputum bacterial smear positive; 2. respiratory virus antigen positive; 3. hyphae and spores were found in smear; 4. acid fast staining was found in smear; 5. PPD (48h) positive; 6. respiratory failure, requiring mechanical ventilation; 7. hemophagocytic syndrome; 8. serious liver failure or renal insufficiency; 9. congenital heart disease; 10. heart failure; 11. kidney disease; 12. connective tissue disease; 13. immunodeficiency disease; 14. tumor; 15. a history of hypertension, history of diabetes mellitus; 16. recurrent respiratory tract infection; 17. Congenital Bronchopulmonary dysplasia; 18. abnormal liver function or blood sodium retention, osteoporosis; 19. history of long-term use of glucocorticoid; 20. allergy history; 21. there are contraindications to the use of corticosteroids, azithromycin; 22. use of immunosuppressant within 1 week; 23. undergoing testing drugs or instruments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fever clearance time;The recovery rate of lung lesion; | — |
Countries
China
Contacts
Public ContactXu Baoping
Beijing Children's Hospital, Capital Medical University
Outcome results
None listed